Tag: LLM Biosecurity
LLM dual-use risk, bioweapon uplift evaluations, ASL safety levels, biosecurity governance for AI models
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What ASL-3 Actually Means: Anthropic’s Biorisk Threshold Explained
ASL-3 is Anthropic’s threshold where models could provide serious uplift on bioweapons with mass casualty potential. What the Virology Capabilities Test actually evaluates, how the 4x novice uplift…
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DNA Synthesis Screening Cannot Keep Up With AI-Designed Sequences
The IGSC DNA synthesis screening standard was built on sequence homology to known pathogens. AI-designed sequences achieve dangerous functions through novel sequences that homology checks cannot recognize. What…
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Evo 2: The Genomic Foundation Model Trained on 9.3 Trillion DNA Bases
Evo 2 from Arc Institute is a 40B-parameter genomic foundation model trained on 9.3 trillion DNA bases spanning all domains of life. How the 128K context architecture works,…
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How Protein Language Models Learned to Design Dangerous Proteins
Researchers used three open-source protein design models to bypass DNA synthesis screening in 2025. Here is how protein language models work, why training data exclusion fails as a…
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LLMs Give Novice Biologists 4x Uplift on Dangerous Tasks
A 2026 study measured LLM access giving novice biologists a 4.16x accuracy boost on biosecurity-relevant tasks, including beating expert baselines. Here is the mechanism and what it means…




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